Ocular Therapeutix is developing sustained release corticosteroids for the treatment of post-operative inflammation and pain following ophthalmic surgery. Inserted non-invasively through the punctum, the product resides within the canaliculus, delivering the drug to the ocular surface over a four week period. The plug also contains a visualization aid for patient and physician retention monitoring over the treatment period. After therapy is complete, the hydrogel resorbs and exits the nasolacrimal system, so there is no need for removal.
About post-operative inflammation…
About Post-operative Inflammation
Punctum Plug Depot
Post-operative inflammation is a common side effect following any ophthalmic surgery. Due to this, physicians prescribe anti-inflammatories such as corticosteroids following ocular surgery as the standard of care. This not only helps manage the symptom, but also provides faster recovery for the patient.Approximately 4.5 million corticosteroid prescriptions were filled in 2010,1 and it is estimated that over 5 million ocular surgeries will take place in 2012 the United States alone.2 Although corticosteroids are beneficial for treatment of post-surgical inflammation, some steroid regimens may cause spikes in intraocular pressure due to the high levels of drug and frequent dosing required.
Steroid-loaded punctum plugs may be able to treat post-operative inflammation without causing spikes in intraocular pressure. Additionally, the one-time administration may improve compliance and convenience, resulting in better disease control.