Ocular Therapeutix’s proprietary hydrogel technology is a two-part synthetic liquid system that is mixed just prior to application. When the solutions are mixed, the material “crosslinks” to form a hydrogel that is soft, lubricious and flexible. The hydrogel contains linkages which gradually hydrolyze in the presence of water at a predetermined rate, gradually sloughing off in the patients tears. The hydrogel is composed substantially of water and polyethylene glycol (PEG), widely considered an inert and biocompatible material. Ocular Therapeutix’s hydrogel technology is the subject of several issued patents.
PEG-based materials are used in a broad number of medical products including drugs, injectables, and implants. As a result, PEG-based materials have undergone extensive biocompatibility and safety testing and enjoy broad market acceptance. The synthetic nature of these materials eliminates the risks or complications associated with medical technologies based on biological components.
Biocompatibility
ReSure Adherent Ocular Bandage has passed all required ISO 10993 biocompatibility testing for this type of product, including testing for cytotoxicity, sensitization, ocular irritation and systemic toxicity. In additional in vivo studies, ReSure hydrogel elicited minimal tissue reaction from both intraocular tissues and corneal tissue.
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To learn more about other applications using Ocular Therapeutix’s hydrogel technology, click here.
For frequently asked questions regarding the ReSure Adherent Ocular Bandage, click here.