Ocular Therapeutix’s proprietary hydrogel based drug delivery technology enables the use of drugs that are known to be efficacious for ocular diseases and conditions when formulated as drops or injections, into one-time or several month dosage forms. The release of these drugs can be tailored to produce the required efficacy with an improved safety profile, since they are used in lower peak concentrations and are preservative-free.
Sustained Release Drug Delivery
Ocular Therapeutix is able to encapsulate a wide range of ophthalmic pharmaceuticals within its hydrogel to deliver sustained and therapeutic levels of drugs to targeted ocular tissues. When necessary, secondary encapsulation with microparticles can be tailored to provide the desired duration of therapy (from days to months), and are compatible with a wide range of ophthalmic medications.
The hydrogel provides containment, localization and protection from inflammatory response, providing what we believe is an ideal material for sustained delivery of drugs to the eye. Ocular’s intracanalicular inserts can be inserted non-invasively through the punctum for ocular surface or anterior segment therapies. Sustained drug delivery inserts also provides more consistent dosing therapy than topical eye drops by avoiding the large variance in drug concentration (see figure below). The hydrogel can also be engineered to be injected intravitreally for posterior segment therapies.
Benefits of sustained ocular drug delivery over topical dosing methods include:
- Improved compliance
- Reduced dosing frequency
- Sustained delivery over time
- Reduced patient burden for greater convenience
- May improve safety and efficacy
Ocular Therapeutix’s first FDA-approved medical device, ReSure(R) Sealant, is a two-part synthetic liquid system that is mixed just prior to application, whereupon the material “crosslinks” and is applied to an incision as a soft, lubricious and flexible (hydrogel) sealant. The hydrogel contains linkages which gradually hydrolyze in the presence of water at a predetermined rate, gradually sloughing off in the patient’s tears.